Burn Center of Research Excellence (BCoRE)
Mission statement:
To be a Center for Excellence in Research covering the entire spectrum of burn injury, from microscopic alterations at the cellular level to the clinical care of the whole person to the impact of burn injuries on society. This includes injury prevention, disaster planning, initial response and resuscitation, critical care, pain control, infectious complications, nutrition, surgical management, wound care, psychosocial issues and long term rehabilitation.
Goals:
To facilitate collaboration in basic science and clinical research across the disciplines of microbiology, biochemistry, medicine, surgery, nursing, physical therapy, psychology and occupational therapy, in order to:
- Increase the scientific knowledge related to burn injuries and resulting complications
- Develop new tools and strategies for the clinical care of acutely injured patients
- Describe epidemiologic characteristics of burn injuries
- Develop protocols for injury prevention and disaster/ mass casualty planning
- Investigate novel strategies in the management of acute and chronic wounds
- Create effective and integrated protocols for pain control, stress disorder, long term rehabilitation and transition to regular life post- burn injury
- Leverage emerging technologies to improve clinical care of acutely injured patients (Machine learning, image processing, artificial intelligence, etc.)
- Leverage the built environment to allow for streamlined care of acutely injured patients
Objectives:
- Develop research collaborations between clinical and basic science departments within 甜瓜视频
- Develop research collaborations between 甜瓜视频 and UMC
- Broaden the impact of our scientific work through publications, presentations at national meetings and collaborations with outside institutions involved in burn research
- Broaden the impact of our scientific work through innovation and entrepreneurship (甜瓜视频 Innovation hub, Regional and NSF I-Corp grants)
Got Questions?
If you are interested in participating in, or would like more information about this research endeavor, please contact us.
Kendra Rumbaugh, PhD
Faculty:
Background:
The topic of burns and wounds has been a fertile ground for research at 甜瓜视频 for
several years, with multiple peer reviewed publications and presentations at national
and international meetings. The burn research program has also facilitated the involvement
of 甜瓜视频 faculty, residents, medical students and undergraduates in basic science
and clinical research, providing the first research opportunity for many junior investigators.
The designation as a 甜瓜视频 Research Center of Excellence will serve to recognize
these efforts both intra and extramurally, as well as develop the basic and clinical
science infrastructure in order to be competitive for grant funding at both local
and national levels. Formalization as a center will also facilitate access by students
from all schools at 甜瓜视频 as well as promote collaboration with outside organizations
and individuals. Finally, a designated center of excellence will promote national
recognition of the scientific work being done at 甜瓜视频 and help recruit talented
individuals interested in this area of research at all levels.
Burn care has historically been a multidisciplinary field from its inception as a separate specialty in the 1950s, with physicians, nurses, wound care technicians, physical therapists, occupational therapists and psychologists being recognized as equally important to the well-being of the burned patient. Perhaps in no other field of medicine is the concept of a team approach so firmly embedded. This is evident even at the national level with the American Burn Association (ABA) leadership comprised of representation from all specialties. This approach is well suited to translational research and collaboration, and is a likely factor in the high research productivity of the burn center despite a relatively small core physician faculty.
BCoRE Related Activities:
Dr. Abdul Hamood
Kruczek C, Qaisar U, Colmer-Hamood JA, Hamood AN. 2013. Serum influences the expression of Pseudomonas aeruginosa quorum-sensing genes and QS-controlled virulence genes during early and late stages of growth. MicrobiologyOpen. doi: 10.1002/mbo3.147 (Epub ahead of print).
Kyle G. Miller, Phat L. Tran, Cecily L. Haley, Matt Myntti, Jane A. Colmer-Hamood, and Abdul N. Hamood. A Novel Agent That Inhibits Biofilm Development by Gram-positive and Gram-negative Wound Pathogens (submitted).
CH Foundation: Abdul Hamood (PI), 01/01/2014-12/30/2014, Title: A Potential Therapy for Burn Wound Infections
Dr. John Griswold
A Retrospective Study Analyzing Aesthesia Intubation Criteria in Burn Patients @
International Anesthesia Research Society (IARS) and Society of Critical Care Anesthesia
(SOCCA) Research Conference, Seattle, WA, May 18-20, 2024
Sara Syed Ahmend B.S., Emily Brumfield B.S., Sulaiman Karim B.S., Heba Alghoul M.D., Theophilus Pham M.D., Alan Pang, M.D., & John Griswold M.D. Antihistamines vs. Resuscitation Requirements and Rate of Complications in Burn Injuries: A Retrospective Study. American Association for the Surgery of Trauma, Poster Presentation, Sept 20-23, 2023. Accepted
Brown E, Koshy R, Credo R, Grossman H, Hardy K, Rizvi M, Alshaikhsalama M, Devega R, Bharadia D, Pang AW, Griswold J. Autologous keratinocyte suspension in conjunction with fibrin sealant for the treatment of partial thickness burns. John A. Boswick M.D. Burn and Wound Healing Symposium, 2022. Podium Presentation.
Pang AW, Pham T, Raghuram A, Zeitouni J, Aickareth G, Dang M, Bharadia D, Griswold J. Comparison of Amalgatome SD to standard dermatome for surgical excision of burns and skin graft harvesting. John A. Boswick M.D. Burn and Wound Healing Symposium, 2022.
Perabo, A, Robison, K, Pang, AW, Bharadia, D, Griswold, J. 鈥淟idocaine and Ketamine as Sedation for Burn Wound Care in a Pediatric Patient: a case report.鈥� North Texas Chapter of American College of Surgeons Annual Meeting, Poster Presentation, 2022.
Zeitouni, J, Pang, AW, Bradshaw, E, Rizvi, M, Bharadia, D, Griswold, J. 鈥淎lkali injury with non-operative management in a pediatric patient: a case report.鈥� North Texas Chapter of American College of Surgeons Annual Meeting, Poster Presentation, 2022.
Bruce, J, McGregor, A, Kesey, J, Pang, AW, Griswold, J. 鈥淐harge capture in the BICU: Increasing Revenue by Improving Documentation.鈥� North Texas Chapter of American College of Surgeons Annual Meeting, Podium Presentation, 2022.
Koshy, R, Brown, E, Pang, AW, Bharadia, D, Griswold, J. 鈥淧ostoperative Splinting vs free range of motion and effect on healing time of ReCell for partial thickness burns.鈥� North Texas Chapter of American College of Surgeons Annual Meeting, Podium Presentation, 2022.
Bradshaw, E, Pang, AW, Bharadia, D. 鈥淯sing Geography as a Predictive Factor of Outcomes in Burn Care Follow-up in Rural West Texas.鈥� North Texas Chapter of American College of Surgeons Annual Meeting, Poster Presentation, 2022.
Brown E, Koshy R, Credo R, Grossman H, Hardy K, Rizvi M, Alshaikhsalama M, Devega R, Bharadia D, Pang AW, Griswold J. 鈥淩ange of motion in ReCell plus STSG vs STSG alone in 2nd and 3rd degree burns.鈥� North Texas Chapter of American College of Surgeons Annual Meeting, Poster Presentation, 2022.
Pang AW, Pham T, Felan S, Raghuram A, Terry M, Bharadia D, Griswold J. Autologous
skin cell suspension application for toxic epidermal necrolysis: a case report. American
Burn Association Annual Conference, Poster Presentation, 2022.
2022 American Burn Association Annual Conference 鈥� Las Vegas, Nevada
Acute Intermittent Porphyria in a Burn Patient: Case Study and Review of the Literature. Credo, Roald Send mail to Credo R.; Kesey, Jennifer; Bharadia, Deepak; Griswold, John; Pang, Alan. Journal of Burn Care and Research. Volume 45, Issue 3, Pages 790 - 7951 May 2024.
Assessing resuscitation in burn patients with varying degrees of liver disease. Abla, Habiba; Tran, Viviea; Pang, Alana; Stroever, Stephanie, Shaw, Chip; Dissanaike, Sharmila; Griswold, John. Burns. Volume 50, Issue 4, Pages 991 - 996. May 2024.
Paul Glat, MD; Lisa Quirk, CRNP; Scott Hultman, MD; Jennifer Kesey, PhD; Arpana Jain, MD; John Griswold, MD; Fitzgerald Natalie, BSN; Lucy Wibbenmeyer, MD; Hamed Amani, MD; Caryn Cramer, PhD, ; William L Hickerson, MD, 鈥淓stablishing Consensus of Best Practice for CEA Use in Treatment of Severe Burns: A US Burn Provider Delphi Study鈥� Epicel Consensus Manuscript. Accepted April 2024
Report of outcomes in burn patients enrolled in the Cultured epidermal autograft prospective Registry. Fagan, Shawn; Hassan, Zaheed; Homsombath, Bounthavy; Sood, Rajiv; Hardy, Kade; Craft-Coffman, Beretta; Hartman, Brett C.; Cramer, Caryn; Griswold, John. Burns Open Open Access Volume 8, Issue 1, Pages 29 - 34. January 2024.
Abla, Habib MS; Pang, Alan MD; Shaw, Chip PhD; Bharadia, Deepak MD, MPH, FACS,; Griswold, John MD, FACS 鈥淎ssessing Resuscitation Needs in Burn Patients with Varying Degrees of Liver Disease鈥� Journal of the American College of Surgeons Accepted January 2024
Arden Perabo, Kathryn Keeney, Alan Pang, MD, Deepak Bharadia, MD, John Griswold MD. 鈥淟idocaine and Ketamine as Sedation for Burn Wound Care in a Pediatric Patient: a Case Report鈥�. Journal of Acute Care Surgery. Submitted November 2023.
Roald Credo, BS MS, Elizabeth Brown, BS, Zheyar Seyan, BS, Elwin Rutayomba, BS, Taylor Prosser, BS, Alan Pang, MD and John Anthony. Griswold, MD FACS. 鈥淚nvestigation of Operating Time with Autologous Skin Cell Suspension on Burn Patients. American College of Surgeons. Accepted May 24, 2023
Elizabeth Brown, Michael Dang, Alan Pang, MD., Senja Collins, Abbye Dixon, Deepak Bharadia, MD. John Griswold, MD. 鈥淪erial Casting for the improvement of joint contracture after burn injury, a case report鈥� Burns. Published June 2023
Bruce J, McGregor A, Garcia H, Banafshay K, Brumfield E, Pang A, Bharadia D, Griswold J. 鈥淐harge Capture in the BICU: Increasing Revenue by Improving Documentation Behaviors鈥� Burns. Submitted March 2023
A modern-day research model for large academic institutions: A fellow-based solution. Alan Pang, Jad Zeitouni, Ferris Zeitouni, Jennifer Kesey, John Griswold. Surgery in Practice and Science. Volume 14, September 2023.
Kopel J, Moreno T, Singh S, Van-Spronsen N, Sorensen G, Griswold J. Central diabetes insipidus and burn trauma. Scars, Burns & Healing. 2022;8.
Ferris Zeitouni, MS, Christina Zhu, BS, BA, Alan Pang, MD, Scott O鈥橞anion, PharmD, Deepak Bharadia, MD, MPH, John Griswold, MD. Vitamin A-Induced Hypercalcemia in Burn Patients: A Case Study. Journal of Burn Care & Research, Volume 43, Issue 6, November/December 2022, Pages 1445鈥�1448.
Schmitz B, Griswold JA: 鈥淎irway Management in Burn Patients鈥�, Airway Management. Benumof & Hagberg 3rd edition. 2013, 44: pp 902-909
Griswold JA: "Burns: Physical and Chemical Injuries", Conn's Current Therapy. editor: Rakel RE. W.B. Saunders Co., 1996, pp 1127-1131
Mitchell M, Griswold J: "Management of Multiple Trauma." In: General Surgery. editors: Ritchie WP, Steele G, Dean RH. Philadelphia. J.B. Lippincott, 1995,pp.919-928.
Griswold JA: "Sodium Concentrations and Burn Shock Resuscitation." Problems in General Surgery. J.B. Lippincott, 1994, 11:4, pp. 566-576
WTPENA Trauma Symposium. Recent Advances in Burn Care and Recovery. [10/21/2021]
UMCP Grand Rounds. Burns & Minor Trauma. [6/22/2021]
Trauma Grand Rounds 甜瓜视频 El Paso. Update on evaluation and early management of the burn injured patient. [5/20/2021]
Southern Region Burn Conference Live Event. Virtual tour of the TJH Burn Center. [2/16/2021]
Dr. Alan Pang
2024 Texas Tech Accelerator Start-Up Grant 鈥� Industry Advancement Technology (iAT) accelerator track 鈥� CEO 鈥� Burn Length of Stay (BloS)
2023 National Science Foundation Innovation Corp regional grant 鈥� Primary Investigator
Great Lakes Regional I-Corps Hub Program 鈥� Spring Cohort #2 Machine learning image
processing of thermal injury
2023 Texas Tech University Amarillo Regional Innovation Corp Program - Machine learning
image processing of inhalational injury
2022 CH Foundation Grant 鈥� Market Research funding for machine learning in burns University of California 鈥� Berkeley Regional Innovation Corp Program - Machine learning image processing of thermal injury Texas Tech University Regional Innovation Corp Program -Supply chain management for fecal transplants
Abla, H, Pang, AW, Shaw, C, Bharadia, D, Griswold, J. Assessing Resuscitation Needs in Burn Patients with Varying Degrees of Liver Disease, Journal of the American College of Surgeons. 2022;235(5):S275-S275. DOI: 10.1097/01.XCS.0000895168.51755.c4.
Grossman, H, Pang, AW, Griswold, J. Treatment of Severe Road Rash with ReCell Autologous Skin Cell Suspension. Journal of Burn Care & Research. 2023;44(3):731-733. https://doi.org/10.1093/jbcr/irad028
Pang A, Abla H, Felan S, Griswold J. Autologous skin cell suspension in toxic epidermal necrolysis: a case series. Journal of Burn Care and Research. 2023;44(2):481-484. https://doi.org/10.1093/jbcr/irac182
Credo, R,Pang, AW, Griswold, J. Acute Intermittent Porphyria in a Burn Patient: Case Study and Review of the Literature. J Burn Care Res. Published online September 20, 2023;irad135.
Adu, Y, Pang, AW, Johnston, R, et. al. Risk Factors for Reintubation and Subsequent
Mortality: A Retrospective Study. May 2024. Poster Presentation. 2024 International
Anesthesia Research Society: Anesthesia and Analgesia 鈥� Seattle, Washington
Adams, E, Pang, AW, Johnston, R, et. al. A retrospective study analyzing anesthesia
intubation criteria in burn patients. May 2024. Poster presentation. 2024 International
Anesthesia Research Society: Anesthesia and Analgesia 鈥� Seattle, Washington
Agyare, K, Pang, AW, Johnston, R, et. Al. Risk factors for Unplanned ICU and Hospital
Admissions Following Elective Surgeries: A Retrospective Study. May 2024. Poster Presentation.
2024 International Anesthesia Research Society: Anesthesia and Analgesia 鈥� Seattle,
Washington
Pang, AW, Li, Y, Chong, J. Deep Learning and Mechanical Ventilation Period Based Inhalational
Injury Score. American Burn Association Annual Conference. April 2024. Podium Presentation.
2024 American Burn Association Annual Conference 鈥� Chicago, Illinois
Bandaru, V, Pang, AW, Griswold, J, et al. Implementation of a Checklist in Burn Surgery:
Usage Improves Operation Efficiency and Cost. Southern Region Burn Conference. November
2023. Podium Presentation. 鈥� 1st place overall in podium presentations. 2023 36th
Annual Southern Region Burn Conference 鈥� Birmingham, Alabama
Bingi, P, Griswold, J, Pang, AW, et. al. Increased Intraoperative Hypothermia in Burn
Patients Administered Famotidine Pre-operatively. October 2023. Poster Presentation.
2023 26th Annual Trauma and Critical Care Symposium 鈥� Lubbock, Texas
Bradshaw, E, Pang, AW, Bharadia, D, Griswold, J. 鈥淯sing Geography as a Predictive
Factor of Outcomes in Burn Care Follow-up in Rural West Texas.鈥� Telehealth Week, Accepted
for Poster Presentation, 2023. 2023 1st Annual Texas Tech University Health Science
Center Telehealth Week 鈥� Lubbock Texas
Zeitouni, J., Aickareth, G., Pang, AW, Bharadia, D., Griswold, J. The Resemblance
of Chemical Pneumonitis Lung Damage to COVID-19 Lung Damage on a CT Scan: A Case Study,
CHEST Annual Meeting 2022 October 16-19, 2022. Chest. 2022;162(4):A1. https://doi.org/10.1016/S0012-3692(22)03810-7.
Dr. Kendra Rumbaugh
Bjarnsholt T, Buhlin K, Dufr锚ne YF, Gomelsky M, Moroni A, Ramstedt M, Rumbaugh KP, Schulte T, Sun L, 脜kerlund B, R枚mling U. Biofilm formation - What we can learn from recent developments. J Intern Med. 2018 Jun 1. doi: 10.1111/joim.12782. PMID: 29856510
Cornforth DM, Dees JL, Ibberson CB, Huse HK, Mathiesen IH, Kirketerp-M酶ller K, Wolcott RD, Rumbaugh KP, Bjarnsholt T, Whiteley M. Pseudomonas aeruginosa transcriptome during human infection. Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5125-E5134. PMID: 29856510
Everett J, Gabrilska R, Rumbaugh KP, Vikstr枚m E. Assessing Pseudomonas aeruginosa Autoinducer Effects on Mammalian Epithelial Cells. Methods Mol Biol. 2018;1673:213-225. PMID: 29130176
Hamerly T, Everett JA, Paris N, Fisher ST, Karunamurthy A, James GA, Rumbaugh KP, Rhoads DD, Bothner B. Detection of Pseudomonas aeruginosa biomarkers from thermally injured mice in situ using imaging mass spectrometry. Anal Biochem. 2017 Oct 28;539:144-148. PMID:29107579
Smith A.C, Rice A., Sutton R.B., Gabrilska R., Wessel A.K., Whiteley M., and Rumbaugh K.P. Albumin inhibits Pseudomonas aeruginosa quorum sensing and alters polymicrobial interactions. Infect Immun. 2017 Jun 19. pii: IAI.00116-17. doi: 10.1128/IAI.00116-17. PMID: 28630071
Watters C, Everett JA, Haley C, Clinton A, Rumbaugh KP. Insulin Treatment Modulates the Host Immune System To Enhance Pseudomonas aeruginosa Wound Biofilms. Infect Immun. 2014 Jan;82(1):92-100.
Filiatrault MJ, Tombline G, Wagner VE, Van Alst N, Rumbaugh K, Sokol P, Schwingel J, Iglewski BH. 2013. Pseudomonas aeruginosa PA1006, Which Plays a Role in Molybdenum Homeostasis, Is Required for Nitrate Utilization, Biofilm Formation, and Virulence. PLoS One.8(2):e55594. doi: 10.1371/journal.pone.0055594. Epub 2013 Feb 8. PMID:23409004
A. Korgaonkar , U. Trivedi , K.P. Rumbaugh , M. Whiteley. 2013. Community surveillance enhances P. aeruginosa virulence during polymicrobial infection. Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):1059-64. PMID:23277552
Watters C., Deleon K., Trivedi U., Griswold J.A., Lyte M., Hampel K.J., Wargo M.J., Rumbaugh K.P. 2013. Pseudomonas aeruginosa biofilms perturb wound resolution and antibiotic tolerance in diabetic mice. Med Med Microbiol Immunol. 2013 Apr;202(2):131-41. (recommended by F1000)
2013 14th International Conference on Pseudomonas (Lausanne, Switzerland). Profiling Pseudomonas aeruginosa wound infections with high-throughput genomic methods. K.H. Turner, U. Trivedi, K. Rumbaugh and M. Whiteley. Selected for Oral Presentation
2013 American Society for Microbiology (New Orleans, LA). Chemotaxis contributes to Pseudomonas aeruginosa virulence in a thermally injured mouse model of infection. J Everett, K Turner, M Whitely, and K Rumbaugh. Samuel Kaplan Award (1stplace poster presentation)
2013 American Society for Microbiology (New Orleans, LA). The Effects of Albumin on Pseudomonas aeruginosa Quorum Sensing in the Chronic Wound Environment. A Clinton, J Chavez, Y Mechref, K Rumbaugh. Samuel Kaplan Award (2nd place poster presentation)
2013 American Society for Microbiology (New Orleans, LA). Antibiotic Resistance in Diabetic and Non-Diabetic Wounds. U Trivedi, S Parameswaran, A Armstrong, S Dissanaike and K Rumbaugh . Poster presentation
2013 American Society for Microbiology (New Orleans, LA). The Role of Clostridium perfringens in Multi-Species Wound Biofilms. H Sparks, S DeLeon, A Clinton and K Rumbaugh. Poster presentation
2013 American College of Surgeons (Washington, DC) and American Society for Microbiology (New Orleans, LA). 伪-Amylase Inhibits Staphylococcus aureus Biofilms. D Fleming, U Trivedi and K Rumbaugh. Poster presentation
2013 American Society for Microbiology (New Orleans, LA). Pseudomonas aeruginosa quorum sensing in chronic wound infections. AR Cueva, A Armstrong, J Everett, D Fleming, K Turner, M Whiteley and K Rumbaugh. Poster presentation
2013 American Society for Microbiology (New Braunsfels, TX). Is quorum sensing involved in the pathogenesis of Pseudomonas aeruginosa in chronic wound infections? Armstrong A., Haley C., Chavez J., Mechref Y., KP Rumbaugh. Poster presentation, Orville Wyss Award for Medical Microbiology, First Place.
2013 American Society for Microbiology (New Braunsfels, TX). 伪-Amylase Inhibits Staphylococcus aureus Biofilms. Fleming D., Trivedi U., K.P Rumbaugh. Poster presentation, Orville Wyss Award for Medical Microbiology, Honorable Mention.
2013 American Society for Microbiology (New Braunsfels, TX). Insulin treatment modifies the mammalian immune response to enhance Pseudomonas aeruginosa wound biofilms. Watters, C., Haley, C., Clinton, A., Rumbaugh, K. P. Charlie Gauntt Award, 2nd place for outstanding oral presentation.
2013 American Society for Microbiology (New Braunsfels, TX). Inhibition of quorum sensing in a wound-like environment prevents Pseudomonas aeruginosa from killing Staphylococcus aureus. Clinton A., DeLeon S., Chavez J., Mechref Y., KP Rumbaugh. Poster presentation
2013 American Society for Microbiology (New Braunsfels, TX). Pseudomonas aeruginosa chemotaxis towards serum in a thermally injured mouse model of infection. Everett J. and KP Rumbaugh. Poster presentation
2013 American Society for Microbiology (New Braunsfels, TX). Interactions of Pseudomonas aeruginosa and Staphylococcus aureus in dual-species wound biofilms. DeLeon S., Fowler H., Clinton A., KP Rumbaugh. Poster presentation
2013 甜瓜视频 Student Research Day. Serum Albumin Influences Quorum Sensing in Pseudomonas aeruginosa. Jamerson J., Clinton A., Rumbaugh, K. P. Poster presentation, won 1st place for junior medical student competition
2013 甜瓜视频 Student Research Day. Utilization of Molecular Sequencing Methods to Characterize the Microflora of Burn Wounds During Initial Hospital Admission. Parameswaran S., Trivedi U., Rumbaugh K., Dowd S., Vega D., Wolcott R., Dissanaike S., Griswold G. Poster presentation
2013 CHD Bioscience, Fort Collins, CO. 鈥淭reatments for Common Wounds.鈥� Invited seminar
Extramural awards funded
- Laura W. Bush Institute for Women鈥檚 Health (Rumbaugh, Co-PI) 2013-1015 $20,000 鈥淕ender Disparity in Burn Injury Survival鈥�
- Army Research Office (Rumbaugh, Sub-contract PI; Whiteley, PI) 2013-2017 $194,981 (total subcontract) 鈥淧olymicrobial virulence mechanisms in chronic wounds鈥�
- CHD Bioscience (Rumbaugh, PI) 2013-2014 $15,100 鈥淧reclinical efficacy study of Veriox to treat chronic wound infections鈥�
Grants submitted and pending approval
- NIH/NIAID R15 (Rumbaugh, PI) $448,435 鈥淧seudomonas aeruginosa and Staphylococcus aureus Interspecies Interactions in Wounds鈥�
- NIH/NIAID R21 (Rumbaugh, Subcontract-PI) $188,586 (total subcontract) 鈥淕enetic determinants of bacterial fitness in polymicrobial wound infections鈥濃�傗��
Grants submitted but not funded
- NIH/NIAID STTR (Rumbaugh, Sub-contract PI; Kaufmann, PI) $305,529 (total subcontract) 鈥淩ecombinant Human Anti-Pseudomonas Polyclonal Antibodies As Anti-Infectives鈥�