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When the School of Medicine opened in 1972 the Department of Pharmacology was among the small number of basic science departments. At its start, the department had only three faculty members (Joseph R. Bianchine, M.D. PhD was the departments first chair) and was located in Drane Hall on the Texas Tech University Campus. Dr. John (Barry) Lombardini, Ph.D. one of the founding faculty members in the department recalls "with three of us teaching the medical pharmacology course to some 36 first year medical students, we brought in a number of quest lecturers and made a lot of follow up phone calls when students had questions about the material". In 1976 the department moved into a new building located on 4th street and Dr. Alexander D. Kenny, Ph.D. became departmental chair a position he would hold for the next 17 years. Under Dr. Kenny the number of faculty in the department expanded to eight and faculty began training both masters and doctoral students.  As Dr. Lombardini recalls "with most faculty having NIH R01 funding and with additional state funding (Tarbox Foundation), the research productivity in the department expanded quickly".  By 1993 under the tutelage of a new chair, Dr. Lou Chiodo, Ph.D., the mission and name of the department expanded to include the field of neuroscience and the number of faculty in the department nearly doubled. This focus continued under the departments next chair, Dr. Reid Norman, Ph.D. (2000-2014) and the department became the home of the South Plains Alcohol and Addiction Center (SPAARC), a school of medicine center of excellence. 

The Department of Pharmacology and Neuroscience is currently chaired by As Dr. Neugebauer explains “We are in the middle of a major period of growth and transformation from traditionally strong expertise in the area of alcohol and addiction to pain and related neuropsychiatric disorders. Great collegiality and collaborative work environment are hallmarks of our departmental culture. We are strengthening existing interactions with basic scientists at �����Ƶ and TTU while building translational bridges with our clinical departments”. As part of this transformation, SPAARC has evolved into the Center of Excellence for Translational Neuroscience and Therapeutics (CTNT) with a faculty membership of greater than 30 basic scientists and clinicians. This new emphasis on translational strategies has also been incorporated into the name and mission of the graduate training program (Translational Neuroscience and Pharmacology). In addition to this research mission, the core faculty within the department are continuing the long tradition of pursuing excellence in medical education and graduate training and this has been reflected in the number of research, teaching, and service awards that departmental faculty have received over the years. In addition, graduates of the department's doctoral program have gone on to have very successful careers both in and outside of academia and this is in part reflected in that  several doctoral trainees have been selected as Distinguished Alumni by the �����Ƶ Graduate School of Biomedical Sciences (e.g. Dr. Susan K. Paulson, (‘82);  Sasanka Ramanadham, Ph.D., ('85)).