泫圖弝け

Luis Cuello, Ph.D.
Professor, Dept. of Cell Physiology and Molecular Biophysics, 泫圖弝け
Research expertise/interest: How do conformational changes of ion channel structures define their biological function?
Keywords: Thermodynamic, ion channel kinetics, protein structure, crystallography, electrophysiology, fluorescence spectroscopy, continuous wave electron paramagnetic resonance spectroscopy, isothermal titration calorimetry and microscale thermophoresis.

Boris Decourt, Ph.D. 
Assistant Professor, Pharmacology and Neuroscience
Research Interests: Neurobiologist specializing in biomarker development and in translational drug development approaches using inflammation modulators to study the molecular pathophysiological changes taking place at early stages of neurological disorders, with the ultimate goal of slowing down or curing the diseases via early intervention before severe neurodegeneration and dementia occur.

Petar Grozdanov, Ph.D.
Assistant Professor, Dept. Pharmacology and Neuroscience
Keywords: Regulation of gene expression by alternative polyadenylation, Molecular mechanisms of alternative polyadenylation, Alcohol use disorder, Alzheimer's disease, Intellectual disability syndromes, Epilepsy, Neurodegenerative diseases, Aging. 

Vadivel Ganapathy, Ph.D.
Professor, Dept. of Cell Biology and Biochemistry, 泫圖弝け
Research interest: Ketogenic diets and exercise are known to be effective in reducing the risk and improving the symptoms of Alzheimer���s disease. We hypothesize that the lactate receptor mediates the beneficial effects of exercise and the niacin receptor mediates the beneficial effects of ketogenic diets. We investigate this issue using a double-knockout mouse that lacks both receptors. We have already shown that the double-knockout mice exhibit increased memory loss. To understand the role of amyloids in the process, we have crossed this double-knockout mouse with a humanized mouse that expresses mouse APP with mutations mimicking human APP. We also study the role of ketone bodies in brain function and in blood-brain barrier integrity using a knockout mouse that lacks Hmgcs2, the rate-limiting enzyme in ketogenesis. In another project, we investigate the role of the amino acid transporter SLC38A5 in BBB endothelial cells in the delivery of critical amino acids to the brain. This transporter has been shown to be obligatory for the delivery of serine to the brain where it is subsequently converted into D- serine, the endogenous potentiator of glutamate signaling.
Keywords: Alzheimer���s disease; lactate receptor; niacin receptor; ketone bodies and brain function; ketone bodies and angiogenesis; blood-brain barrier; amino acid delivery to brain

Nadia German, Ph.D.
Associate Professor, Department of Pharmaceutical Sciences, School of Pharmacy, 泫圖弝け

Josee Guindon, D.V.M., Ph.D.
Associate Professor, Dept, of Pharmacology and Neuroscience, 泫圖弝け
Research Interests: Behavioral pharmacology, immunohistochemistry, molecular biology (RT-PCR, Western blot), animal pain models (inflammatory, neuropathic, surgical), modulation of pain pathways (exercise, etc.), kidney physiological pathways

Breanna N. Harris, Ph.D.
Assistant Professor, Dept. of Biological Sciences, TTU
Research Expertise/Interest: stress-responses at various biological levels in health, anxiety, feeding, and risk-taking behaviors, reproduction, cognitive function, and aging, in animals and humans

George Henderson, Ph.D.
Professor, Dept. of Pharmacology and Neuroscience, 泫圖弝け
Research Interests: Alcohol, environmental toxins, neurons, gila, apoptosis, oxidative stress

Michaela Jansen, Ph.D.
Professor, Dept. of Cell Physiology and Molecular Biophysics, Associate Dean for Medical Education and Accreditation, 泫圖弝け
Research Expertise/Interest: Mechanisms, functions and drug targets of neurotransmitter receptors and their protein networks. Mechanisms of clinically used drugs and novel drug target discovery and characterization.
Keywords: Drug targets, protein-protein interactions, molecular pharmacology, molecular biology, pharmacology

Guangchen Ji, Ph.D.
Research Associate Professor, Dept. of Pharmacology and Neuroscience, 泫圖弝け
Research Interests: Electrophysiological single-cell recordings in different brain areas and various behavioral assays to correlate neuronal activity with pain-related behavior

Andrey Karamyshev, Ph.D.
Associate Professor, Dept. of Cell Biology and Biochemistry, 泫圖弝け
Research Expertise/Interest: Molecular mechanisms of human diseases, neurodegenerative disorders, regulation of protein synthesis and protein transport.
Keywords: Molecular and cellular biology; human diseases; neurodegenerative disorders; translational control; protein synthesis; ribosome; RNA stability and degradation; protein quality control

Zemfira Karamysheva, Ph.D.
Associate Professor, Dept. of Cell Biology and Biochemistry, 泫圖弝け
Research Expertise/Interest: mRNA translation and ribosome specialization and their dysregulation in human diseases, including neurodegenerative and other neurological diseases, as well as translational control in drug resistance

Irene La-Beck, PharmD
Assistant Professor, Dept. of Immunotherapeutics & Biotechnology, 泫圖弝け-Abilene

J. Josh Lawrence, Ph.D.
Associate Professor, Dept. of Pharmacology and Neuroscience, 泫圖弝け
Research Expertise/Interest: nutritional deficiencies, excitation/inhibition balance in disease states, hippocampal neuromodulation, aging, Alzheimer���s disease, epilepsy, autism.

Hongjun Liang, Ph.D.
Professor, Dept. of Cell Physiology and Molecular Biophysics, 泫圖弝け

Aric Logsdon, Ph.D.
Assistant Professor, Pharmacology and Neuroscience, 泫圖弝け
Research Expertise/Interest: Blood-brain Barrier Physiology, Traumatic Brain Injury and Stroke, Neuroinflammation and Neurodegeneration, Alzheimer's Disease and Related Dementias, Neuropharmacology and Brain-drug Delivery, Glycobiology and Glycomics

Clinton MacDonald, Ph.D.
Professor, Dept. of Cell Biology and Biochemistry, 泫圖弝け
Research Expertise/Interest: Mechanisms tissue-specific mRNA polyadenylation including brain and testis. Molecular biology of X-linked intellectual disability. Mechanisms of mRNA processing in spermatogenesis.
Keywords: Gene expression, molecular biology, mRNA processing, polyadenylation, neurodevelopment, spermatogenesis

Maria Manczak, Ph.D.
Research Assistant Professor, Garrison Institute on Aging and Department of Neurology, 泫圖弝け

Lance McMahon, Ph.D. 
Professor, SOP, Senior Vice President for Research and Innovation, 泫圖弝け

Volker Neugebauer, M.D., Ph.D.
Professor and Chair, Dept. of Pharmacology and Neuroscience, 泫圖弝け, Executive Director, Garrison Institute on Aging, 泫圖弝け 
Research Expertise/Interest: Brain research, neuroplasticity in health and disease; chronic pain and opioids, neurodegenerative diseases (Alzheimer���s disease), anxio-depressive comorbidities; preclinical models and approaches, human tissue analyses, studies and interventions in humans.

Igor Ponomarev, Ph.D.
Associate Professor, Dept. of Pharmacology and Neuroscience, 泫圖弝け
Research Interests: Molecular mechanisms of cellular plasticity in models of Alcohol Use Disorder. Neurogenomics. Drug repurposing.

Andrew Shin, Ph.D.
Assistant Professor, Dept. of Nutritional Sciences, TTU
Research: Understanding how the brain controls metabolism and nutrient partitioning as well as the long-term regulation of body weight and appetite and the underlying mechanisms of Roux-en-Y gastric bypass (RYGB) surgery. Understanding the role of insulin action in the brain in regulating branched-chain amino acid (BCAA) metabolism and how this central control can contribute to glucose homeostasis by using molecular, pharmacological, transgenic, surgical, and integrative physiological approaches
Keywords: neuroendocrinology, inter-organ crosstalk, gut hormones, satiety hormones, obesity, diabetes, neurodegeneration, gut microbiota, HPA axis, brain manipulation, opto/chemogenetics, autonomic denervation, pancreatic clamps, other integrative physiological and behavioral in vivo tests, metabolism, obesity, diabetes, bariatric surgery, brain function, and neurodegenerative diseases

Jenny Wilkerson, Ph.D.
Assistant Professor, Dept. of Pharmaceutical Sciences, 泫圖弝け-Amarillo
Research: Pain, Drug addiction/dependence, natural product drug development
Keywords: peripheral neuropathic pain, cancer pain, drug dependence/abuse, drug discovery

Hongmin Wang, Ph.D.
Professor, Dept. of Pharmacology and Neuroscience, 泫圖弝け
Research Interests: My research focuses on neuroprotection and repair of the damaged brain involved in Alzheimer���s disease and ischemic stroke. We are particularly interested in the role of proteostasis and some specific transcription factors in the pathogenesis of these diseases. Using both genetically modified mice and cell models, including the cultured stem cells, as well as multiple approaches, we aim at (1) investigating the pathogenic mechanisms of the diseases, (2) identifying the targets that can be ���druggable��� for the disorders, and (3) screening and validating the therapeutic agents that can be used for treating these diseases.
Keywords: Alzheimer���s disease, ischemic stroke, proteostasis, neurodegeneration, neuroinflammation, neuroprotection, therapeutics.