Nadezhda German Laboratory

About Us

Welcome to the German lab, founded in 2015 and located at Texas Tech University Health Sciences Center in Amarillo. Our work is at the interface of chemistry and medicine, where we work towards the design, synthesis, and pre-clinical evaluation of small molecules with therapeutic potential. Current research projects include design and synthesis of GPCR ligands, particularly opioid receptor ligands, aimed towards the treatment of neuropathic pain, depression, addiction, and alcoholism. Our second area of interest is the design, synthesis and pharmacological evaluation of compounds as potential treatment of triple-negative breast cancer (TNBC).

                        
                        Research Interest
                        
                        Design and synthesis of GPCR ligands 
Evaluation of compounds as potential treatment of triple-negative breast cancer (TNBC)

The Team

Siavash Shahbazi Nia

Ph.D. Candidate/ Research Assistant

Sadisna Shahi

Graduate Student/ Research Assistant

Anoushka Bhat

Graduate Student / Research Assistant

Rayna Bandy

Graduate Student / Research Assistant

Mohammad Anwar Hossain (current position: Postdoctoral trainee at UNC)

Md Ashraf Uz Zaman (current position: Postdoctoral trainee at Baylor)

Content 2 Here

1. Ashraf-Uz-Zaman M, Bhalerao A, Mikelis C, Cucullo L, German N. Assessing the Current State of Lung Cancer Chemoprevention: A Comprehensive Overview. Cancers. 2020;12(5).

2. Jayaraman S, Al Shoyaib A, Kocot J, Villalba H, Alamri FF, Rashid M, Wangler NJ, Chowdhury EA, German N, Arumugam TV, Abbruscato TJ, Karamyan VT. Peptidase neurolysin functions to preserve the brain after ischemic stroke in male mice. Journal of neurochemistry. 2020;153(1):120-137.

3. Hossain MA, Sattenapally N, Parikh HI, Li W, Rumbaugh KP, German N. Design, synthesis, and evaluation of compounds capable of reducing Pseudomonas aeruginosa virulence. European journal of medicinal chemistry. 2020;185:111800.

4. Nguyen T, Gamage TF, Decker AM, German N, Langston TL, Farquhar CE, Kenakin TP, Wiley JL, Thomas BF, Zhang Y. Diarylureas Containing 5-Membered Heterocycles as CB1 Receptor Allosteric Modulators: Design, Synthesis, and Pharmacological Evaluation. ACS chemical neuroscience. 2019;10(1):518-527.

5. Dukat M, Jain A, German N, Ferrara-Pontoriero R, Huang Y, Ma Y, Schulte MK, Glennon RA. Desformylflustrabromine (dFBr): A Structure-Activity Study on Its Ability To Potentiate the Action of Acetylcholine at 伪4尾2 Nicotinic Acetylcholine Receptors. ACS chemical neuroscience. 2018;9(12):2984-2996.

6. Ashraf-Uz-Zaman M, Sajib MS, Cucullo L, Mikelis C, German N. Analogs of penfluridol as chemotherapeutic agents with reduced central nervous system activity. Bioorganic & medicinal chemistry letters. 2018;28(23-24):3652-3657.

7. Patel R, Hossain MA, German N, Al-Ahmad A. Gliotoxin penetrates and impairs the integrity of the human blood-brain barrier in vitro. Mycotoxin research. 2018;34(4):257-268.

8. Gandhi K, Li C, German N, Skobowiat C, Carrillo M, Kallem RR, Larumbe E, Martinez S, Chuecos M, Ventolini G, Nathanielsz P, Schlabritz-Loutsevitch N. Effect of maternal high-fat diet on key components of the placental and hepatic endocannabinoid system. American journal of physiology. Endocrinology and metabolism. 2018;314(4):E322-E333.

9. Sajib S, Zahra FT, Lionakis MS, German N, Mikelis C. Mechanisms of angiogenesis in microbe-regulated inflammatory and neoplastic conditions. Angiogenesis. 2018;21(1):1-14.

10. Nguyen T, German N, Decker AM, Langston TL, Gamage TF, Farquhar CE, Li JX, Wiley JL, Thomas BF, Zhang Y. Novel Diarylurea Based Allosteric Modulators of the Cannabinoid CB1 Receptor: Evaluation of Importance of 6-Pyrrolidinylpyridinyl Substitution. Journal of medicinal chemistry. 2017;60(17):7410-7424.

11. Ranjan A, German N, Mikelis C, Srivenugopal KS, Srivastava SK. Penfluridol induces endoplasmic reticulum stress leading to autophagy in pancreatic cancer. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 2017;39(6):1010428317705517.

12. Hao X, L眉thje F, R酶nn R, German N, Li X, Huang F, Kisaka J, Huffman D, Alwathnani HA, Zhu YG, Rensing C. A role for copper in protozoan grazing - two billion years selecting for bacterial copper resistance. Molecular microbiology. 2016;102(4):628-641.

13. Schlabritz-Loutsevitch N, German N, Ventolini G, Larumbe E, Samson J. Fetal Syndrome of Endocannabinoid Deficiency (FSECD) In Maternal Obesity. Medical hypotheses. 2016;96:35-38.

14. Taudte N, German N, Zhu YG, Grass G, Rensing C. Restoration of growth by manganese in a mutant strain of Escherichia coli lacking most known iron and manganese uptake systems. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 2016;29(3):433-50.

15. German N, L眉thje F, Hao X, R酶nn R, Rensing C. Microbial Virulence and Interactions With Metals. Progress in molecular biology and translational science. 2016;142:27-49.

16. Durham PG, Zhang Y, German N, Mortensen N, Dhillon J, Mitchison DA, Fourie PB, Hickey AJ. Correction for Spray Dried Aerosol Particles of Pyrazinoic Acid Salts for Tuberculosis Therapy. Molecular pharmaceutics. 2015;12(10):3782.

17. Durham PG, Zhang Y, German N, Mortensen N, Dhillon J, Mitchison DA, Fourie PB, Hickey AJ. Spray Dried Aerosol Particles of Pyrazinoic Acid Salts for Tuberculosis Therapy. [Corrected]. Molecular pharmaceutics. 2015;12(8):2574-81.

18. Hao X, L眉thje FL, Qin Y, McDevitt SF, Lutay N, Hobman JL, Asiani K, Soncini FC, German N, Zhang S, Zhu YG, Rensing C. Survival in amoeba--a major selection pressure on the presence of bacterial copper and zinc resistance determinants? Identification of a "copper pathogenicity island". Applied microbiology and biotechnology. 2015;99(14):5817-24.

19. Nguyen T, German N, Decker AM, Li JX, Wiley JL, Thomas BF, Kenakin TP, Zhang Y. Structure-activity relationships of substituted 1H-indole-2-carboxamides as CB1 receptor allosteric modulators. Bioorganic & medicinal chemistry. 2015;23(9):2195-2203.

20. Perrey DA, German N, Decker AM, Thorn D, Li JX, Gilmour BP, Thomas BF, Harris DL, Runyon SP, Zhang Y. Effect of 1-substitution on tetrahydroisoquinolines as selective antagonists for the orexin-1 receptor. ACS chemical neuroscience. 2015;6(4):599-614.

21. German N, Decker AM, Gilmour BP, Gay EA, Wiley JL, Thomas BF, Zhang Y. Diarylureas as allosteric modulators of the cannabinoid CB1 receptor: structure-activity relationship studies on 1-(4-chlorophenyl)-3-{3-[6-(pyrrolidin-1-yl)pyridin-2-yl]phenyl}urea (PSNCBAM-1). Journal of medicinal chemistry. 2014;57(18):7758-69.

22. German N, Decker AM, Gilmour BP, Thomas BF, Zhang Y. Truncated Orexin Peptides: Structure-Activity Relationship Studies. ACS medicinal chemistry letters. 2013;4(12):1224-1227.

23. German N, Doyscher D, Rensing C. Bacterial killing in macrophages and amoeba: do they all use a brass dagger?. Future microbiology. 2013;8(10):1257-64.

24. Perrey DA, German N, Gilmour BP, Li JX, Harris DL, Thomas BF, Zhang Y. Substituted tetrahydroisoquinolines as selective antagonists for the orexin 1 receptor. Journal of medicinal chemistry. 2013;56(17):6901-16.

25. German N, Kim JS, Jain A, Dukat M, Pandya A, Ma Y, Weltzin M, Schulte MK, Glennon RA. Deconstruction of the 伪4尾2 nicotinic acetylcholine receptor positive allosteric modulator desformylflustrabromine. Journal of medicinal chemistry. 2011;54(20):7259-67.

updated: 10/11/2022

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