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Pharmaceutical Sciences

Graduate Student / Research Assistant Lab Phone: 806-414-9256 E-Mail: sesharma@ttuhsc.edu Mail Address: 1300 S Coulter Amarillo, TX 79106-1712

Biography

Sejal Sharma completed his Doctor of Pharmacy (PharmD) degree from Rajiv Gandhi University of Health Sciences, Karnataka, India in 2018. He joined the Graduate Program in Pharmaceutical Sciences as a Doctor of Philosophy (PhD) student in January of 2020, and is presently working in the laboratory of Dr. Thomas Abbruscato with the Department of Pharmaceutical Sciences in Amarillo.

Education:

• PharmD: Rajiv Gandhi University of Health Sciences, Karnataka, India, 2018

Research Interests:

Ischemic Stroke; Blood-Brain Barrier; Effects of tobacco smoking and E-cig vaping on cerebrovascular system; Brain Pharmacokinetics; Drug Repurposing.

Publications:

   Before Admission to GPPS:

• Balakeshwa Ramaiah, Sejal Sharma, Saroj Poudel, Raju Koneri. Development and Validation of an Instrument to Enhance the Community Pharmacy Practitioner’s Knowledge toward Handling of High Risk/Alert Medications. J Biomed Pharm Sci. 2019;2(1):1000118.
• Balakeshwa Ramaiah, Sejal Sharma, Saroj Poudel, Raju Koneri. Development and Validation of an Instrument to Assess Nurse Practitioners Knowledge towards Handling of High-Risk/High-Alert Medications. Global Journal of Medical Research: K Interdisciplinary, [S.I.]. Feb. 2019. ISSN 2249-4618, Volume XIX Issue I Version I, Page: 21-29

   After Admission to GPPS:

• Sharma S, Zhang Y, Akter KA, Nozohouri S, Archie SR, Patel D, Villalba H, Abbruscato T. Permeability of Metformin across an In Vitro Blood-Brain Barrier Model during Normoxia and Oxygen-Glucose Deprivation Conditions: Role of Organic Cation Transporters (Octs). Pharmaceutics. 2023 Apr 28; 15(5):1357.
• Archie SR, Sifat AE, Zhang Y, Villalba H, Sharma S, Nozohouri S, Abbruscato TJ. Maternal e-cigarette use can disrupt postnatal blood-brain barrier (BBB) integrity and deteriorates motor, learning and memory function: influence of sex and age. Fluids Barriers CNS. 2023 Mar 10; 20(1):17.
• Zhang Y, Archie SR, Ghanwatkar Y, Sharma S, Nozohouri S, Burks E, Mdzinarishvili A, Liu Z, Abbruscato TJ. Correction: Potential role of astrocyte angiotensin converting enzyme 2 in the neural transmission of COVID-19 and a neuroinflammatory state induced by smoking and vaping. Fluids Barriers CNS. 2022 Nov 17; 19(1):91. Erratum for: Fluids Barriers CNS. 2022 Jun 7; 19(1):46.
• Barthels D, Prateeksha P, Nozohouri S, Villalba H, Zhang Y, Sharma S, Anderson S, Howlader MSI, Nambiar A, Abbruscato TJ, Das H. Dental Pulp-Derived Stem Cells Preserve Astrocyte Health During Induced Gliosis by Modulating Mitochondrial Activity and Functions. Cell Mol Neurobiol. 2022 Oct 6. Epub ahead of print.
• Sifat AE, Archie SR, Nozohouri S, Villalba H, Zhang Y, Sharma S, Ghanwatkar Y, Vaidya B, Mara D, Cucullo L, Abbruscato TJ. Short-term exposure to JUUL electronic cigarettes can worsen ischemic stroke outcome. Fluids Barriers CNS. 2022 Sep 9; 19(1):74.
• Zhang Y, Archie SR, Ghanwatkar Y, Sharma S, Nozohouri S, Burks E, Mdzinarishvili A, Liu Z, Abbruscato TJ. Potential role of astrocyte angiotensin converting enzyme 2 in the neural transmission of COVID-19 and a neuroinflammatory state induced by smoking and vaping. Fluids Barriers CNS. 2022 Jun 7; 19(1):46.
• Rahman Archie S, Sifat AE, Villalba H, Sharma S, Nozohouri S, Zhang Y, Abbruscato T. Prenatal E‐Cigarette Use Disrupts Blood‐Brain Barrier (BBB) Integrity and Induces Pro‐Inflammatory Cytokines in Postnatal Brain. The FASEB Journal. 2022 May; 36.
• Sharma S, Rahman Archie S, Kanchanwala V, Mimun K, Rahman MA, Zhang Y, Abbruscato T. Effects of Nicotine Exposure From Tobacco Products and Electronic Cigarettes on the Pathogenesis of Neurological Diseases: Impact on CNS Drug Delivery. Front Drug Deliv. 2022 Apr 26; 2:886099.
• Archie SR, Sharma S, Burks E, Abbruscato T. Biological determinants impact the neurovascular toxicity of nicotine and tobacco smoke: A pharmacokinetic and pharmacodynamics perspective. Neurotoxicology. 2022 Mar; 89:140-160. Epub 2022 Feb 9.
• Sharma S, Nozohouri S, Vaidya B, Abbruscato T. Repurposing metformin to treat age-related neurodegenerative  disorders and ischemic stroke. Life Sci. 2021 Jun 1; 274:119343. Epub 2021 Mar 11.

Presentations:

   Before Admission to GPPS:

• Sejal Sharma, Nishan Malla. “Assessment of knowledge of pharmacists on high-risk medications and interpretation on their understandings”. International Symposium on Pharmaceutical Care in Tuberculosis, Karnataka College of Pharmacy, Bangalore, India; December 2017.

   After Admission to GPPS:

• Sejal Sharma, Yong Zhang, Ali Ehsan Sifat, Sabrina Rahman Archie, Saeideh Nozohouri, Thomas Abbruscato. "Evaluation of Influx and Efflux Transporters of Metformin in an In Vitro Blood-Brain Barrier Model During Normoxic and Ischemic Conditions". American Society for Pharmacology and Experimental Therapeutics (ASPET) Annual Meeting, St. Louis, Missouri; May 2023.
• Sejal Sharma, Yong Zhang, Saeideh Nozohouri, Khondker Ayesha Akter, Ali Ehsan Sifat, Sabrina Rahman Archie, Dhaval Patel, Thomas Abbruscato. "Permeability of metformin across an in vitro blood-brain barrier model during normoxia and hypoxia: Role of Organic Cation Transporters (OCTs)". 35th Annual Student Research Week (SRW), �����Ƶ Graduate School of Biomedical Sciences (GSBS) Lubbock; Feb/Mar 2023.
• Sejal Sharma, Yong Zhang, Sabrina Rahman Archie, Thomas Abbruscato. "LC-MS/MS method development and validation for evaluation of brain pharmacokinetic parameters of metformin after an intravenous bolus administration: Application in ischemic stroke". American Association of Pharmaceutical Scientists (AAPS) PharmSci 360, Boston, MA; October 2022.
• Sejal Sharma, Yong Zhang, Sabrina Rahman Archie, Thomas Abbruscato. "In-vitro and in-vivo evaluation of metformin across the blood-brain barrier". 19th Annual Research Days, �����Ƶ Jerry H Hodge School of Pharmacy, Office of Sciences in Amarillo, event at Lubbock, TX; June 2022.
• Sejal Sharma, Sabrina Rahman Archie, Yong Zhang, and Thomas Abbruscato. "In vitro evaluation of metformin across the blood-brain barrier". Student Research Week, �����Ƶ Graduate School of Biomedical Sciences, Lubbock; March 2022.
• Sejal Sharma, Saeideh Nozohouri, Ali Ehsan Sifat, Sabrina Rahman Archie, Yong Zhang, Heidi Villalba, Thomas Abbruscato. "In vitro evaluation of metformin across the blood brain barrier". American Association of Pharmaceutical Scientists (AAPS) PharmSci 360, Philadelphia, PA; October 2021.
• Sejal Sharma, Ali Ehsan Sifat, Yong Zhang, Saeideh Nozohouri, Sabrina Rahman Archie, Heidi Villalba, Thomas Abbruscato. "Mechanism of Metformin Transport Across BBB in Normal Physiological Condition and Ischemic Brain Injury". Research Days, �����Ƶ Jerry H Hodge School of Pharmacy Amarillo (virtual); June 2021.

Seminars:

• 11/09/2022 "The SARS-CoV-2 infection worsens blood-brain barrier integrity in the smoking and vaping population" [Oral Qualifying Exam, public presentation counted as Seminar credit]
• 04/08/2022 "In-vitro and in-vivo evaluation of metformin across the blood-brain barrier"
• 05/07/2021 "Repurposing Metformin in Ischemic Stroke"

Awards/Scholarships:

   Before Admission to GPPS:

• High School Provisional Scholarship, Nepal Education Board.

   After Admission to GPPS:

• Travel Award, American Society for Pharmacology and Experimental Therapeutics (ASPET) Annual Meeting, St. Louis, Missouri; May 2023.
• Travel Grant Award, Cayman Chemical Company, American Association of Pharmaceutical Scientists (AAPS) PharmSci 360, Boston, MA; October 2022.
• Graduate Award for 2022-2023, Helen Hodges Educational Charitable Trust, September 2022.

Memberships:

• Student Ambassadors for Diversity & Inclusion (SADI), �����Ƶ Office of Diversity and Inclusion, 2022-2023 academic year.
• The Honor Society of Phi Kappa Phi (International), �����Ƶ Chapter, 2022-present.
• Graduate Student Association in Amarillo (GSAA), �����Ƶ – Secretary, 2021-2022.
• American Association of Pharmaceutical Scientists (AAPS), 2020-present.
• Graduate Student Association in Amarillo (GSAA), �����Ƶ – Historian, 2020-2021.
• Graduate Student Association in Amarillo (GSAA), �����Ƶ, 2020-present.