泫圖弝け

Pharmaceutical Sciences

Graduate Student / Research Assistant Lab Phone: 806-414-9368 E-Mail: Sadisna.Shahi@ttuhsc.edu Mail Address: 1300 S Coulter Amarillo, TX 79106-1712

Biography

Sadisna Shahi completed her Bachelor of Pharmacy (BPharm) degree from Kathmandu University, Kathmandu, Nepal in 2017. She then worked from 2017-2019 as a Product Executive with Qmed Formulation Private Limited in Kathmandu, Nepal. Sadisna joined the Graduate Program in Pharmaceutical Sciences as a Doctor of Philosophy (PhD) student in August of 2019, and is presently working in the laboratory of Dr. Nadezhda German with the Department of Pharmaceutical Sciences in Amarillo.

Education:

• BPharm: Kathmandu University, Kathmandu, Nepal; 2017

Research Interests:

Medicinal chemistry; Drug discovery, design and synthesis; Biological evaluation of drug compounds.

Publications

• Ashraf-Uz-Zaman M, Ji G, Tidwell D, Yin L, Thakolwiboon S, Pan J, Junell R, Griffin Z, Shahi S, Barthels D, Sajib MS, Trippier PC, Mikelis CM, Das H, Avila M, Neugebauer V, German NA. Evaluation of Urea-Based Inhibitors of the Dopamine Transporter Using the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis. ACS Chem Neurosci. 2022 Jan 19; 13(2):217-228. Epub 2022 Jan 3.
• Ashraf-Uz-Zaman M, Shahi S, Akwii R, Sajib MS, Farshbaf MJ, Kallem RR, Putnam W, Wang W, Zhang R, Alvina K, Trippier PC, Mikelis CM, German NA. Design, synthesis and structure-activity relationship study of novel urea compounds as FGFR1 inhibitors to treat metastatic triple-negative breast cancer. Eur J Med Chem. 2021 Jan 1; 209:112866. Epub 2020 Sep 24.

Presentations:

• Sadisna Shahi, Rayna Bandy, Nadezhda A. German. "Urea-based compound UR-1-1-13 affects the mitochondrial health of triple-negative breast cancer cells". 35th Annual Student Research Week (SRW), 泫圖弝け Graduate School of Biomedical Sciences (GSBS), Lubbock; Feb/Mar 2023.
• Sadisna Shahi, Md Ashraf-Uz-Zaman, Guangchen Ji,  Dalton Tidwell, Linda Yin, Smathorn Thakolwiboon, Jie Pan, Paul C. Trippier, Mirla Avila, Volker Neugebauer,  Nadezhda A. German. "Developing a novel class of DAT inhibitor for the treatment of addiction". Center of Excellence for Translational Neuroscience and Therapeutics (CTNT) & Garrison Institute on Aging (GIA) 6th Annual Symposium, 泫圖弝け, Lubbock; April 2022.
• Sadisna Shahi, Md Ashraf-Uz-Zaman, Guangchen Ji,  Dalton Tidwell, Linda Yin, Smathorn Thakolwiboon, Jie Pan, Paul C. Trippier, Mirla Avila, Volker Neugebauer,  Nadezhda A. German. "Developing a novel class of DAT inhibitor for the treatment of addiction". Student Research Week, 泫圖弝け Graduate School of Biomedical Sciences, Lubbock; March 2022.
• Sadisna Shahi, Md Ashraf-Uz-Zaman, Guangchen Ji,  Dalton Tidwell, Linda Yin, Smathorn Thakolwiboon, Jie Pan, Paul C. Trippier, Mirla Avila, Volker Neugebauer,  Nadezhda A. German. "Treatment of addiction with a novel class of DAT inhibitor". Behavior, Biology, and Chemistry (BBC): Translational Research in Addiction, University of Texas Health Science Center at San Antonio (UTHSCSA), BBC 2022 Annual Meeting, San Antonio, Texas, February 2022.
• Special Poster Collection Session:  Sadisna Shahi, Wei Wang, Racheal G. Akwii, Paul C. Trippier, Constantinos M. Mikelis, Ruiwen Zhang, Nadezhda A. German. "Identification of Novel Compounds with Optimized Toxicological Profile to Treat Brain Metastasized Triple-Negative Breast Cancer". American Association of Pharmaceutical Scientists (AAPS) PharmSci 360, Philadelphia, PA; October 2021.
• Sadisna Shahi, Md Ashraf-Uz-Zaman, Guangchen Ji, Dalton Tidwell, Linda Yin, Smathorn Thakolwiboon, Jie Pan, Paul C. Trippier, Mirla Avila, Volker Neugebauer. Nadezhda A. German. ���Urea-based dopamine transporter inhibitors for the treatment of neurodegenerative diseases.��� Fall 2021 American Chemical Society (ACS) Division of Medicinal Chemistry (MEDI), virtual; August 2021.
• Podium Presentation (Junior Graduate Presentations):  Sadisna Shahi, Wei Wang, Racheal G. Akwii, Paul C. Trippier, Constantinos M. Mikelis, Ruiwen Zhang, Nadezhda A. German. "Urea-based analogs as therapeutic option for brain metastasized triple negative breast cancer." Research Days, 泫圖弝け Jerry H. Hodge School of Pharmacy Amarillo (virtual); June 2021.
• Md Ashraf-Uz-Zaman, Sadisna Shahi, Guangchen Ji, Dalton Tidwell, Linda Yin, Smathorn Thakolwiboon, Jie Pan, Paul C. Trippier, Mirla Avila, Volker Neugebauer, Nadezhda A. German. "Urea-based dopamine transporter inhibitors as a therapeutic option for neurodegenerative diseases." Fifth Annual Research Symposium: Aging-Related Health Issues and Alzheimer���s Disease, Center of Excellence for Translational Neuroscience and Therapeutics (CTNT) and Garrison Institute on Aging (GIA), 泫圖弝け in Lubbock (virtual); May 2021. [presented by Shahi]
• Sadisna Shahi, Wei Wang, Racheal G. Akwii, Paul C. Trippier, Constantinos M. Mikelis, Ruiwen Zhang, Nadezhda A. German. "Development of new therapeutic agents for the treatment of triple-negative breast cancer." ACS Spring 2021, American Chemical Society���s Division of Medicinal Chemistry (MEDI); Virtual; April 2021.
• Sadisna Shahi, Wei Wang, Racheal G. Akwii, Naana Quagraine, Paul C. Trippier, Constantinos M. Mikelis, Ruiwen Zhang, Nadezhda A. German. "Structural activity relationship approach on a novel compound for the treatment of triple negative breast cancer." Student Research Week, 泫圖弝け Graduate School of Biomedical Sciences; Virtual; March 2021.
• Sadisna Shahi, Md Ashraf-Uz-Zaman, Racheal G Akwii, Constantinos M Mikelis, Nadezhda A German. "Novel compounds for the treatment of triple-negative breast cancer with optimized toxicological profile." Student Research Week, 泫圖弝け Graduate School of Biomedical Sciences; March 2020.

Seminars:

• 11/11/2022 "Evaluating the effect of urea-based analogs on the mitochondrial health of cancer cells"
• 11/12/2021 ���Quercetin and its analogs to down-regulate the mutant guardian of the genome in cancer cells" [Oral Qualifying Exam, public presentation counted as Seminar credit]
• 02/12/2021 "Synthesis and evaluation of urea-based analogs for the treatment of TNBC"

Awards/Scholarships:

• Best Oral Presentation of Fall 2022 GPPS Graduate Student Seminar Series. Graduate Student Association in Amarillo (GSAA), 泫圖弝け, rec'd February 2023.
• Registration Scholarship, funded by National Institutes of Health (NIH), Jackson Laboratory: 20th Annual Workshop on the Pathology of Mouse Models for Human Disease, September 2022.
• Mary Lou Clements-Mann Scholarship, 泫圖弝け Graduate School of Biomedical Sciences, Lubbock; September 2022.
• Love of Learning Award, The Honor Society of Phi Kappa Phi (International), September 2022.
• Virtual Participant Registration Award (funded by NIH), 31st Annual Short Course on "Experimental Models of Human Cancer", Jackson Laboratory, Farmington, Connecticut (Virtual); August 2022.
• Travel Award; Behavior, Biology, and Chemistry (BBC): Translational Research in Addiction; University of Texas Health Science Center at San Antonio (UTHSCSA), BBC 2022 Annual Meeting, San Antonio, Texas; February 2022.
• Travel Award, American Association of Pharmaceutical Scientists (AAPS) 泫圖弝け Student Chapter, AAPS PharmSci360, Philadelphia, PA; Fall 2021.
• Mary Lou Clements-Mann Endowed Scholarship, 泫圖弝け Graduate School of Biomedical Sciences (GSBS), Fall 2021.

Memberships:

• Graduate Student Association in Amarillo (GSAA), 泫圖弝け ��� President, 2022-2023.
• The Honor Society of Phi Kappa Phi (International), 泫圖弝け Chapter, April 2022-present.
• Graduate Student Association in Amarillo (GSAA), 泫圖弝け ��� Vice-President, 2021-2022.
• American Association of Pharmaceutical Scientists (AAPS), 2020-present.
• American Association of Pharmaceutical Scientists (AAPS) 泫圖弝け Student Chapter, 2020-present.
• American Chemical Society (ACS), 2020-present.
• Graduate Student Association in Amarillo (GSAA), 泫圖弝け ��� International Student Representative, 2020-2021.
• Graduate Student Association in Amarillo (GSAA), 泫圖弝け, 2019-present