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Immunotherapeutics & Biotechnology

Graduate Student / Research Assistant Lab Phone: 325-696-0423 E-Mail: Shreyas.Gaikwad@ttuhsc.edu Mail Address: 1718 Pine Street, Suite 1302 Abilene, TX 79601

Biography

Shreyas Gaikwad completed his Bachelor of Pharmacy degree from Savitribai Phule Pune University, Pune, India in 2015, and his Master of Science degree in Pharmaceutics from Bharati Vidyapeeth, Pune, India in 2017. Later, he worked for two years as a Scientific and Medical Writer at Springer-Nature Technology and Publishing Solutions in Pune. He joined the Graduate Program in Pharmaceutical Sciences as a Doctor of Philosophy (PhD) student in August of 2019, and is presently working in the laboratory of Dr. Sanjay Srivastava with the Department of Immunotherapeutics and Biotechnology in Abilene.

Education:

• MS: Pharmaceutics, Bharati Vidyapeeth, Pune, India, 2017
• BPharm: Savitribai Phule Pune University, Pune, Maharashtra, India, 2015

Research Interests:

Screening novel agents for their anti-cancer activity and investigating their in-vitro and in-vivo effect against metastatic cancers.

Publications:

• Agrawal MY, Gaikwad S, Srivastava S, Srivastava SK. Research Trend and Detailed Insights into the Molecular Mechanisms of Food Bioactive Compounds against Cancer: A Comprehensive Review with Special Emphasis on Probiotics. Cancers (Basel). 2022 Nov 8; 14(22):5482.
• Gaikwad S, Agrawal MY, Kaushik I, Ramachandran S, Srivastava SK. Immune checkpoint proteins: Signaling mechanisms and molecular interactions in cancer immunotherapy. Semin Cancer Biol. 2022 Nov; 86(Pt 3):137-150. Epub 2022 Mar 24.
• Kaushik I, Ramachandran S, Zabel C, Gaikwad S, Srivastava SK. The evolutionary legacy of immune checkpoint inhibitors. Semin Cancer Biol. 2022 Nov; 86(Pt 2):491-498. Epub 2022 Mar 24.
• Gaikwad S, Agrawal MY, Kaushik I, Ramachandran S, Srivastava SK. Immune checkpoint proteins: Signaling mechanisms and molecular interactions in cancer immunotherapy. Semin Cancer Biol. 2022 Mar 24: S1044-579X(22)00070-0. Epub ahead of print.
• Gupta N, Gaikwad S, Kaushik I, Wright SE, Markiewski MM, Srivastava SK. Atovaquone Suppresses Triple-Negative Breast Tumor Growth by Reducing Immune-Suppressive Cells. Int J Mol Sci. 2021 May 13;22(10):5150.
• Gaikwad S, Srivastava SK. Role of Phytochemicals in Perturbation of Redox Homeostasis in Cancer. Antioxidants. 2021 Jan 9; 10(1), 83.

Presentations:

   Before Admission to GPPS:

• Shreyas Gaikwad, Rucha Joshi, Awdhoot Godbole. “Printing the World and Beyond – Applications of 3D Printing in the Field of Pharmaceutical Sciences”. International Society for Technical Education ISTE Students Chapter, Pune; 2017.

   After Admission to GPPS:

• Shreyas Gaikwad and Sanjay K Srivastava. "Repurposed anti-parasitic compound suppresses pancreatic cancer by modulating immune microenvironment". 19th Annual Research Days, �����Ƶ Jerry H Hodge School of Pharmacy, Office of Sciences in Amarillo, event at Lubbock, TX; June 2022.
• Flash Presentation:  Shreyas Gaikwad and Sanjay K Srivastava. "Bioprinted pancreatic tumor models: A novel animal-free approach for screening chemotherapy, radiotherapy, and immunotherapy".  Summer School on Innovative Approaches in Science, North Carolina Biotechnology Center (NCBC), Durham, NC; June 2022.
• Shreyas Gaikwad and Sanjay K. Srivastava. "Drug repurposing strategies for pancreatic cancer management". American Association for Cancer Research (AACR), New Orleans, LA; April 2022.
• Shreyas Gaikwad and Sanjay K Srivastava. "A Novel Anti-Parasitic Drug Suppresses Pancreatic Cancer by Modulating the Immune Microenvironment". Society of Toxicology (SOT) 61st Annual Meeting & ToxExpo, San Diego, CA; March 2022.
• Shreyas Gaikwad and Sanjay K. Srivastava. "Bioprinted pancreatic cancer-on-chip model for anti-cancer studies". Student Research Week, �����Ƶ Graduate School of Biomedical Sciences, Lubbock; March 2022.
• Shreyas Gaikwad, Nehal Gupta, Itishree Kaushik, Stephen E. Wright, Maciej Markiewski and Sanjay K Srivastava. "Atovaquone Suppresses Triple-Negative Breast Tumor Growth by Reducing Immune-Suppressive Cells". Research Days, �����Ƶ Jerry H Hodge School of Pharmacy, Amarillo (virtual); June 2021.
• Shreyas Gaikwad, Nehal Gupta, Stephen Wright, Maciej Markiewski and Sanjay Srivastava. “Role of Atovaquone in Triple Negative Breast Cancer through modulation of ribosomal protein S19”. 33rd Annual Student Research Week, �����Ƶ Graduate School of Biomedical Sciences, Lubbock, March 2021.
• Oral Presentation: Shreyas Gaikwad. "3D Printing in Healthcare Industry". Invertis University, Bareilly, Uttar Pradesh, India; May 10, 2020. [online international webinar]

Seminars:

• 12/02/2022 "MBO suppresses pancreatic ductal adenocarcinoma by modulating the tumor immune microenvironment"
• 10/01/2021 "MBO: An Option for Pancreatic Cancer Therapy" [Oral Qualifying Exam, public presentation counted as Seminar credit]
• 01/08/2021 "A novel therapeutic option for pancreatic cancer"

Awards/Scholarships:

   Before Admission to GPPS:

• Travel Grant, Novartis Biotechnology Leadership Camp (BioCamp 2016), Hyderabad, India.
• Post Graduate Scholarship (Graduate Pharmacy Aptitude Test), All India Council for Technical Education, Government of India, 2015.

   After Admission to GPPS:

• �����Ƶ President’s Innovative Startup Award for “NeoPurpose Therapeutics” (founding member with Dr. Sanjay Srivastava); October 2022.
• Allevi Fall Grant Recipient, Allevi by 3D Systems, July 2022.
• Travel Award, The Early Career Researchers Advancing 21st Century Science (ERA21). Summer School on Innovative Approaches in Science, North Carolina Biotechnology Center, Durham, NC; June 2022.
• Society of Toxicology (SOT) Mechanisms Specialty Section, Sheldon D. Murphy Student and Postdoctoral Endowment Award, SOT 61st Annual Meeting & ToxExpo, San Diego, CA; March 2022.
• Travel Grant Award, Cayman Chemical Co., Society of Toxicology (SOT) 61st Annual Meeting & ToxExpo, San Diego, CA; March 2022.
• Student Poster Competition Award, Society of Toxicology (SOT) Drug Discovery Toxicology Specialty Section [sponsored by Emil A. Pftizer Endowment Fund], SOT 61st Annual Meeting & ToxExpo, San Diego, CA; March 2022.
• Society of Toxicology (SOT) Supplemental Training for Education Program (STEP) Award, SOT Education and Career Development Committee; January 2022.
• Society of Toxicology (SOT) Science Communications Training Award, "The Essentials" virtual workshop, Alan Alda Center for Communicating Science; October 2021.
• Mary Lou Clements-Mann Endowed Scholarship, �����Ƶ Graduate School of Biomedical Sciences, Fall 2021.
• First Place Junior Graduate Poster Winner, Research Days, �����Ƶ Jerry H Hodge School of Pharmacy, Amarillo (virtual); June 2021.

Memberships:

• Immunotherapeutics and Biotechnology Graduate Student Association (IBGSA) – President, 2021-2022.
• Immunotherapeutics and Biotechnology Graduate Student Association (IBGSA) – Secretary, 2020-2021.
• Immunotherapeutics and Biotechnology Graduate Student Association, (IBGSA), 2019-present.