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Immunotherapeutics & Biotechnology

Graduate Student / Research Assistant Lab Phone: 325-696-0423 E-Mail: pback@ttuhsc.edu Mail Address: 1718 Pine Street, Suite 1302 Abilene, TX 79601

Biography

Patricia Back completed her Bachelor of Pharmacy (BPharm) degree from the Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil, in 2017, and her Master of Science (MS) degree in Pharmaceutical Sciences from the same school in 2019. She joined the Graduate Program in Pharmaceutical Sciences as a Doctor of Philosophy (PhD) student in August of 2021, and is presently working in the laboratory of Dr. Irene La-Beck with the Department of Immunotherapeutics and Biotechnology on our Abilene campus.

Education:

• MS: Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil, 2019.
• BPharm: Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil, 2017.

Research Interests:

Drug delivery, nanotechnology, immunotherapy, cancer chemotherapy.

Publications:

   Before Admission to GPPS:

• Back PI, Balestrin LA, Fachel FNS, Nemitz MC, Falkembach M, Soares G, Marques MS, Silveira T, Dal Prá M, Horn AP, Braganhol E, von Poser GL, Dora CL, Teixeira HF. Hydrogels containing soybean isoflavone aglycones-rich fraction-loaded nanoemulsions for wound healing treatment – in vitro and in vivo studies. Colloids Surf B. 2020, 196, 111301.
• Back PI, Furtado LR, Nemitz MC, Balestrin LA, Fachel FNS, Gomes HM, Schuh RS, Moreira JC, von Poser GL, Teixeira HF. Skin permeation and oxidative protection effect of soybean isoflavones from topical nanoemulsions – a comparative study of extracts and pure compounds. AAPS PharmSciTech. 2018, 19 (7), 3029–3039.
• Daut RM, Back PI, Cardozo NS, Marczaka LDF, Külkamp-Guerreiro IC. Pinhão starch and coat extract as new natural cosmetic ingredients: Topical formulation stability and sensory analysis. Carbohydr Polym. 2015, 134, 573–580.
• Fuentefria AM, Jesus RS, Back PI, Oliveira TV, Knecht H, Külkamp-Guerreiro IC. Ketoconazole-loaded poly(ε-caprolactone) nanocapsules for improved antifungal activity against Candida spp. Lat Am J Pharm. 2014, 33(10), 1589-95.
• Detoni CB, Coradini K, Back PI, Oliveira CM, Andrade DF, Beck RC, Pohlmann AR, Guterres SS. Penetration, photo-reactivity and photoprotective properties of nanosized ZnO. Photochem Photobiol Sci 2014, 13(9): 1253-60.

   After Admission to GPPS:

• Md Rakibul Islam, Jalpa Patel, Patricia Ines Back, Hilary Shmeeda, Konstantin Adamsky, Hui Yang, Carlos Alvarez, Alberto A Gabizon, Ninh M La-Beck. Impact of liposomal drug delivery and alendronate co-encapsulation on the immune modulatory effects of doxorubicin in the tumor microenvironment [abstract]. In: Proceedings of the AACR Special Conference: Tumor Immunology and Immunotherapy; 2022 Oct 21-24; Boston, MA. Philadelphia (PA): AACR; Cancer Immunol Res 2022; 10(12 Suppl):Abstract nr A42.
• Islam MR, Patel J, Back PI, Shmeeda H, Adamsky K, Yang H, Alvarez C, Gabizon AA, La-Beck NM. Comparative effects of free doxorubicin, liposome encapsulated doxorubicin and liposome co-encapsulated alendronate and doxorubicin (PLAD) on the tumor immunologic milieu in a mouse fibrosarcoma model. Nanotheranostics. 2022 Sep 1; 6(4):451-464.

Presentations:

• Patricia Ines Back, Md. Rakibul Islam, Jalpa Patel, Hilary Shmeeda, Rajareddy Kallem, William C. Putnam, Alberto Gabizon, Ninh M La-Beck. "Reprogramming macrophages with liposomal alendronate". University of Colorado (CU) Anschutz Medical Campus, Skaggs School of Pharmacy and Pharmaceutical Sciences, “Mechanisms & Barriers in Nanomedicine” conference-workshop, Golden, CO; May 2023.
• Patricia Ines Back, Qisheng Zhang, Ninh M. La-Beck. "Evaluation of macrophage lipid metabolism after liposomal treatment". 19th Annual Research Days, �����Ƶ Jerry H Hodge School of Pharmacy, Office of Sciences in Amarillo, event at Lubbock, TX; June 2022.
• Patricia Ines Back, Md. Rakibul Islam, Jalpa Patel, Hilary Schmeeda, Maciej Markiewski, Alberto Gabizon, Ninh M. La-Beck. "Toxicity evaluation of liposomal alendronate in combination with PD1 blockading antibodies in a murine melanoma model". Student Research Week, �����Ƶ Graduate School of Biomedical Sciences, Lubbock; March 2022.

Seminars:

• 04/21/2023 "Understanding the metabolism of liposomes in macrophages"

Awards/Scholarships:

• Travel Scholarship (sponsored by NIH), University of Colorado (CU) Anschutz Medical Campus, Skaggs School of Pharmacy and Pharmaceutical Sciences, “Mechanisms & Barriers in Nanomedicine” conference-workshop, Golden, CO; May 2023.

Memberships:

• Immunotherapeutics and Biotechnology Graduate Student Association (IBGSA), �����Ƶ - Communications Officer, 2023-2024
• Immunotherapeutics and Biotechnology Graduate Student Association (IBGSA), �����Ƶ - Communications Officer, 2022-2023
• Immunotherapeutics and Biotechnology Graduate Student Association (IBGSA), �����Ƶ, 2021-present