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Pharmaceutical Sciences

Graduate Student / Research Assistant Lab Phone: 806-414-9255 E-Mail: Yeseul.Ahn@ttuhsc.edu Mail Address: 1300 S Coulter Amarillo, TX 79106-1712

Biography

Yeseul Ahn completed her BS degree in Biochemistry from the University of Minnesota, Minneapolis, Minnesota, USA in 2016. She joined the Graduate Program in Pharmaceutical Sciences as a Doctor of Philosophy (PhD) student in August of 2019, and is presently working in the laboratory of Dr. Ulrich Bickel with the Department of Pharmaceutical Sciences.

Education:

• BS: Biochemistry, University of Minnesota, Minneapolis, Minnesota; 2016

Research Interests:

Understanding the molecular characteristics of drug and other macromolecule delivery systems at blood-brain barrier.

Publications:

   Before Admission to GPPS:

• Ji-Man Park, Minchul Seo, Chang Hwa Jung, Douglas Grunwald, Matthew Stone, Neil Michael Otto, Erik Toso, Yeseul Ahn, Michael Kyba, Timothy J. Griffin, LeeAnn Higgins, and Do-Hyung Kim. ULK1 phosphorylates Ser30 of BECN1 in association with ATG14 to stimulate autophagy induction. Autophagy. 2018;14(4):584–597.

   After Admission to GPPS:

• Behnam Noorani, Ekram Ahmed Chowdhury, Faleh Alqahtani, Yeseul Ahn, Ehsan Nozohouri, Sumaih Zoubi, Dhavalkumar Patel, Laurence Wood, Juyang Huang, Muhammad Bilal Siddique, Abraham Al-Ahmad, Reza Mehvar, Ulrich Bickel. Effects of Volatile Anesthetics versus Ketamine on Blood-Brain Barrier Permeability via Lipid-Mediated Alterations of Endothelial Cell Membranes. J Pharmacol Exp Ther. 2023 May; 385(2):135-145. Epub 2023 Feb 24.
• Noorani B, Cucullo L, Ahn Y, Kadry H, Bhalerao A, Raut S, Nozohouri E, Chowdhury EA. Advanced Microfluidic Vascularized Tissues as Platform for the Study of Human Diseases and Drug Development. Curr Neuropharmacol. 2022 Jul 6. Epub ahead of print.
• Noorani B, Chowdhury EA, Alqahtani F, Sajib MS, Ahn Y, Nozohouri E, Patel D, Mikelis C, Mehvar R, Bickel U. A Semi-Physiological Three-Compartment Model Describes Brain Uptake Clearance and Efflux of Sucrose and Mannitol after IV Injection in Awake Mice. Pharm Res. 2022 Feb 10.
• Lee Y, Ahn Y, Cucullo L. Impact of Physical Activity and Medication Adherence on the Seizure Frequency and Quality of Life of Epileptic Patients: A Population Study in West Texas. Biomed Res Int. 2022 Jan 18;2022:4193664.
• Noorani B, Chowdhury EA, Alqahtani F, Ahn Y, Patel D, Al-Ahmad A, Mehvar R, Bickel U. LC-MS/MS-based in vitro and in vivo investigation of blood-brain barrier integrity by simultaneous quantitation of mannitol and sucrose. Fluids Barriers CNS. 2020 Oct 14;17(1):61.

Presentations:

   Before Admission to GPPS:

• Yeseul Ahn, Alex Krona, Aaron Kurtti, Eric Collins, Irina St. Louis. “CELF1 phosphorylation and function in response to DNA damage”. Howard Hughes Medical Institute (HHMI) Undergraduate Research Symposium, University of Minnesota Twin Cities, St. Paul, MN; May 2015.

   After Admission to GPPS:

• Yeseul Ahn, Ehsan Nozohouri, Sumaih Zoubi, Ulrich Bickel. "Trafficking pathway of T-cell receptor mimic antibodies (TCRm) RL6A in human brain-derived endothelial cells". American Society for Pharmacology and Experimental Therapeutics (ASPET) of Experimental Biology (EB), St. Louis, Missouri; May 2023.
• Yeseul Ahn, Ehsan Nozohouri, Sumaih Zoubi, Ulrich Bickel . "Internalization and Trafficking Pathway of T-Cell Receptor Mimic Antibodies (TCRm) RL6A in Human Brain Endothelial Cells at the Blood Brain Barrier (BBB)". American Association of Pharmaceutical Scientists (AAPS) PharmSci360, Boston, MA; October 2022.
• Yeseul Ahn, Ehsan Nozohouri, Sumaih Zoubi, Ulrich Bickel. "Internalization and endocytic pathway of T-cell receptor mimic antibodies (TCRm) RL6A in human brain endothelial cells". 19th Annual Research Days, �����Ƶ Jerry H Hodge School of Pharmacy, Office of Sciences in Amarillo, event at Lubbock, TX; June 2022.
• Yeseul Ahn, Behnam Noorani, Chanakya Patil, Ehsan Nozohouri, Dhavalkumar Patel, Ulrich Bickel. "Effect of isoflurane anesthesia on ceftazidime brain uptake". American Association of Pharmaceutical Scientists (AAPS) PharmSci 360, Philadelphia, PA; October 2021.
• Yeseul Ahn, Behnam Noorani, Chanakya Patil, Dhavalkumar Patel, Ulrich Bickel. "Effect of Isoflurane Anesthesia on Ceftazidime Brain Uptake". Research Days, �����Ƶ Jerry H Hodge School of Pharmacy Office of Sciences, Amarillo (virtual); June 2021.

Seminars:

• 11/11/2022 "Trafficking pathway of T-cell receptor mimic antibodies (TCRm) RL6A in human brain-derived endothelial cells"
• 09/24/2021 "Quantitative and Qualitative Measurements of Blood-Brain Barrier (BBB) Permeability Impairments in an Alzheimer's Disease (AD) Transgenic Mouse Model" [Oral Qualifying Exam presentation counted as Seminar credit]
• 02/26/2021 "Effect of isoflurane anesthesia on ceftazidime brain uptake"

Awards/Scholarships:

   Before Admission to GPPS:

• Howard Hughes Medical Institute (HHMI) Science Education Fellowship, “CELF1 phosphorylation and function in response to DNA damage” project; January – August 2015.

   After Admission to GPPS:

• Travel Award, American Society for Pharmacology and Experimental Therapeutics (ASPET) of (EB), St. Louis, Missouri; May 2023.
• Best Oral Presentation of Fall 2022 GPPS Graduate Student Seminar Series. Graduate Student Association in Amarillo (GSAA), Sp'23.
• Phonathon Endowed Scholarship, �����Ƶ Student Government Association, February 2022 [to be applied graduating term].
• Travel Award, American Association of Pharmaceutical Scientists (AAPS) �����Ƶ Student Chapter, AAPS PharmSci360, Philadelphia, PA; Fall 2021.
• Phonathon Scholarship, �����Ƶ Student Government Association, Spring 2021 [to be applied Summer 2021].

Memberships:

• Graduate Student Association in Amarillo (GSAA), �����Ƶ – Student Senate Representative, 2021-2022.
• Graduate Student Association in Amarillo (GSAA), �����Ƶ – Secretary, 2020-2021.
• Graduate Student Association in Amarillo (GSAA), �����Ƶ, 2020-present.