Dr. Chhanda Bose | Texas Tech University Health Sciences Center

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Chhanda Bose, PhD

Chhanda Bose

Chhanda Bose, PhD

Research Associate Professor, Department of Internal Medicine

Curriculum Vitae

 

March 2019—present
Internal Medicine Department, Texas Tech University for Health Science Center, Lubbock, TX

Explore the role of RLIP76 (a mercapturic acid pathway transporter), and proteins that regulate this pathway (p53 and HSF1) in carcinogenesis and cancer therapy. This project addresses the overarching challenges of: (a) Identify what drives breast cancer initiation; determine how to prevent it; and (b) Identify mechanisms of effective treatment regimens to refine or replace them with ones that are more effective, less toxic, and impact survival, In Vivo and in Vitro. The projects are:

  • Treatment of triple negative breast cancer xenografts:  Nu/Nu Athymic Nude female mice (NOD/scid) injected sub-cutaneous with TMD231-luc2 or MDA-MB-231BR-luc2 cells (firefly luciferase expressing derivatives of MDA-MB-231 that develop lung or brain metastases, respectively). Primary tumor growth as well as metastases are determined by in-vivo bioluminescence imaging IVIS LUMINA XR in vivo imaging system (CALIPER LIFE SCIENCES) weekly. 
  • Rlip depletion by antisense phosphorothioate oligodeoxynucleotide (APO) R508 and/or 2HF, In Vitro in Vivo. Nu/Nu athymic nude mice are used to create subcutaneously implanted human cancer xenografts of cultured human cancer cells from non-small cell and melanoma cell lines with differing functionality of the P53, ALK-kinase or B-Raf genes.
  • Prevention of chemical carcinogenesis by utilizing female C57Bl6 mouse model to assess the chemo preventative activity of 2HF.   
  • Prevention of Spontaneous Carcinogenesis: Study the effect of chemo preventative substances in MMTV-ErbB2/P53-/- (p53 null) and MMTV-ErbB2/P53+/- mouse models. 
  • Small Inhibitor Therapeutic Target for Alzheimer’s disease. Studying the efficacies of a small molecule ‘DDQ’ in amyloid beta precursor protein transgenic mice for Alzheimer’s disease. 
 
  • Sanjay Awasthi, Chhanda Bose, Catherine Jones, Rakhshanda Rahman, Sharad S. Singhal, and Sharda P. Singh. Partial RALBP1 loss depletes DNA repair pathway genes. Accepted for presentation in The 42nd Annual San Antonio Breast Cancer Symposium, San Antonio, Texas, United States, December 10 – 14, 2019.
  • Griffin Sue W, Parcon P, Balasubramaniam M, Bose C, JoAnn Biedermann, Robert E Mark. IL-1Facilitaion of Autophagy by Parkin Activation via NEDD8 Binding to the pUb site is foiled by downregulating PINK1 and favoring plaque and Tangle pathology. Presented in 14th International Conference on Alzheimer’s and Parkinson’s disease, Lisbon, Portugal, March 26-31, 2019.
  • Griffin Sue W, Parcon P, Balasubramaniam M, Bose C, JoAnn Biedermann, Robert E Mark. IL-1Influences Autophagy by mediating upregulation of Parkin and Parkin neddylation in cell culture and animal models, and mimics the pattern seen in AD brain. Presented in 46th Annual Meeting of Society For Neuroscience, San Diego, CA, Nov.3-7, 2018.
  • Griffin Sue W, Parcon P, Balasubramaniam M, Bose C, Farlow Martin, Mark Robert. IL-1 and NEDD8 Demonstrate divergent Effects on Parkin and PINK-1. Presented in 47th Annual Meeting of Society For Neuroscience, Washington DC, Nov.11-15, 2017.
  • Malik Bilal, Bose C, Shah SV. Iron Chelation Ameliorates Fibrotic Pathways in ZSF1 Obese Rat. Presented in 49th Annual Meeting of the American Society of Nephrology, Chicago, IL Nov. 15-20, 2016.
  • Bose C, Shah SV, Karaduta OK, Basnakian AG, Kaushal GP. Induction of autophagy and its role in endothelial cell injury in response to carbamylated low-density lipoprotein (cLDL). Presented at the 48th Annual Meeting of the American Society of Nephrology, San Diego, CA, Nov. 5-8, 2015.
  • Bose C, Shah SV, Gokden N, Megyesi J, Karaduta O, Swaminathan S. Collagen-secreting angiogenic macrophages in diabetic nephropathy. Presented at the 46th Annual Meeting of the American Society of Nephrology, Atlanta, GA, Nov. 5-10, 2013.
  • Swaminathan S, Bose C, Hiatt KM, Shah SV. Omniscan-induced CD163+ ferroportin+ osteogenic cells in nephrogenic systemic fibrosis. Presented at the 45th Annual Meeting of the American Society of Nephrology, SanDiego, CA, Nov 1-4, 2012.
  • Bose C, Gokden N, Shah SV, Swaminathan S. Effect of iron chelator deferiprone on progression of chronic kidney disease in mouse models. Presented at the 44th Annual Meeting of the American Society of Nephrology, Philadelphia, PA, Nov. 2011. J Am Soc Nephrol 22:852A, 2011
  • Swaminathan S, Bose C, Shah SV, Hiatt KM. Effect of gadolinium contrast on iron metabolism pathway and inhibition by iron chelator. Presented at the 43rd Annual Meeting of the American Society of Nephrology, Denver, CO, Nov. 16-21, 2010. J Am Soc Nephrol 21:720A, 2010.
  • Bose C, Shah SV, Hiatt KM, Swaminathan S. Oral iron chelator deferiprone prevents nephrogenic systemic fibrosis in mice. Presented at the 43rd Annual Meeting of the American Society of Nephrology, Denver, CO, Nov. 16-21, 2010. J Am Soc Nephrol 21:770A, 2010.
  • Swaminathan S, Bose C, Hall KA, Hiatt KM, Shah SV. Iron metabolism pathway in NSF: In vitro effect on Omniscan and inhibition by iron chelator. Presented at the Fourth Annual Symposium on Nephrogenic Systemic Fibrosis and Gadolinium Based Contrast Agents, New York Academy of Sciences, New York City, NY, May 14-15, 2010.
  • Bose C, Hiatt KM, Shah SV, Swaminathan S. Oral iron chelator deferiprone prevents nephrogenic systemic fibrosis in mice. Presented at the Fourth Annual Symposium on Nephrogenic Systemic Fibrosis and Gadolinium Based Contrast Agents, New York Academy of Sciences, New York City, NY, May 14-15, 2010.
  • Swaminathan S, Bose Chhanda, Shah SV, Hiatt KM. Role of CD163+, Tie-2+ collagen secreting angiogenic macrophages in gadolinium-induced cardiac vascular and systemic fibrosis. Presented at the 42nd Annual Meeting of the American Society of Nephrology, SanDiego, CA, 2009. J Am Soc Nephrol 20:693A, 2009.
  • Bose C, Udupa KB. Low density lipoprotein receptor expression and mitogen-activated protein kinase activation during in vitro aging. Presented at the 60th Annual Scientific Meeting of the Gerontological Society of America, San Francisco, CA, Nov.16-20, 2007.
  • Bose C, Udupa KB. Involvement of Mitogen Activated protein Kinase Signals in Erythropoietin Induced proliferation Of Tumor Cells. Accepted for Oral presentation at the XXXIth Annual Scientific Meeting of the International Society of Hematology, Casino Punta del Este, Uruguay, March.20-24, 2007.
  • Udupa KB, Bose C. Identification of erythroid cell stimulating factor as a unique protein. Quiescin 6: role in erythropoiesis. Presented at the 47th Annual Meeting of the American Society of Hematology, Atlanta, GA, Dec.10-13, 2005.
  • Udupa KB, Bose C. Erythropoietin signaling in tumor cells: differential activation of mitogen activated protein kinases and their effect upon cell survival. 10th Congress of the European Hematology Association, Stockholm, Sweden, June 2-5, 2005.
  • Bose C, Bhuwaneshwaran C, Udupa KB. Reduced Signaling by extracellular regulatory kinases (ERK) is one of the causes for the decreased low density lipoprotein receptor expression in old fibroblasts. 56th Annual Scientific Meeting of the Gerontological Society of American, San Diego, CA, Nov. 22-26, 2004.
  • Bose C, Bhuwaneshwaran C, Udupa KB. Expression and activation of mitogen activated protein kinase (MAKP) in normal human fibroblast- Effect of in vitro aging. 55th Annual Scientific Meeting of the Gerontological Society of America, Boston, MA, Nov. 22-26, 2003.
  • Bose C, Bhuwaneshwaran C, Udupa KB. 54th Annual Scientific Meeting of the Gerontological Society of America, Chicago, IL, Nov.14-19, 2002.
  • Bose C, Saini M, Upadhyay SN. Tumor-bearing immunocompromised mice as a model for evaluating immunomodulatory compounds against opportunistic infections. Indo-French symposium on Immunopharmacology. National Institute on Immunology, New Delhi, India, Dec.1-5, 1997.
  • Bose C, Singh SP, Chatterji RK, Srivastava VML. Susceptibility of rodent host to Litomosoides carinii infection: Role of macrophage effector system. Global Meet on Parasitic Diseases, New Delhi, India, March 18-23, 1996.
  • Bose C, Agarwal SK, Chatterji RK, Srivastava VML. Effect of carboline antifilarials compounds on metabolism in Litomosoides carinii. Twelfth National Congress of Parasitology, Panjim Goa, India, Jan. 23-25, 1995.
  • Zaidi A, Singh SP, Bose C. Effect of diaminoalkane antileishmanial compound on metabolic activities of L. donovani amastigotes. Eleventh National Congress of Parasitology, Udaipur, India, Jan 23-25, 1994.
  • Bose C, Agarwal SK, Chatterji RK, Srivastava VML. Carboline antifilarials: Effect on sugar metabolism in Litomosoides carinii. Eleventh National Congress of Parasitology, Udaipur, India, Jan 23-25, 1994.
  • Bose C, Chatterji RK, Srivastava VML. Effects on carbohydrate metabolizing enzymes in Litomosoides carinii63rd Annual Meeting of Society of Biological Chemists (India) CDRI, Lucknow, India, Dec. 19-22, 1993.
  • Bose C, Chatterji RK, Srivastava VML. Diaminoalkane antifilarials: Effect on sugar metabolism in Litomosoides carinii. 62nd Annual Meeting of Society of Biological Chemists (India) CDRI, Lucknow, India, Dec. 19-22, 1992.
  • Bose C, Chatterji RK, Srivastava VML. Effect of carboline antifilarials on sugar metabolism in Litomosoides carinii. CSIR Golden Jubilee Symposium on Tropical Diseases: Molecular Biology and Control Strategies (India), Central Drug Research Institute, Lucknow, India. Feb. 17-20, 1992.
  • Bose, C., Singh, S.P., Igid, H., Green, W.C., Singhal, S.S., Lee, J., Palade, P.T., Rajan, A., Ball, S., Tonk, V., Hindle, A., Tarbox, M., Awasthi, S. (2019) Topical 2′-Hydroxyflavanone for Cutaneous Melanoma. Cancers 11, 1556.
  • Bose, C., Awasthi, S., Sharma, R., BeneÅ¡, H., Hauer-Jensen, M., Boerma, M., and Singh, S. P. (2018) Sulforaphane potentiates anticancer effects of doxorubicin and attenuates its cardiotoxicity in a breast cancer model, PloS one 13, e0193918.
  • Marquis BJ, Louks HP, Bose C, Wolfe RR, Singh SP. (2017) A New Derivatization Reagent for HPLC-MS Analysis of Biological Organic Acids. Chromatographia 80 (12):1723-1732. doi: 10.1007/s10337-017-3421-0. Epub 2017 Oct 29. PMID: 29213145
  • Chhanda Bose, Sudhir V. Shah, Oleg K. Karaduta, and Gur P. Kaushal. (2016) Carbamylated low-density lipoprotein (cLDL)-mediated induction of autophagy and its role in endothelial cell injury. PLoS One Dec 14; 11(12):e0165576. doi: 10.1371/journal.pone.0165576. PMID: 27973558
  • Shukla AM, Bose C, Karaduta OK, Apostolov EO, Kaushal GP, Fahmi T, Segal MS, Shah SV.    (2015) Impact of hydroxychloroquine on atherosclerosis and vascular stiffness in the presence of chronic kidney disease. PLoS One 10(9):e0139226. PMID: 26414017
  • Bose C, Megyesi JK, Shah SV, Hiatt KM, Hall KA, Karaduta O, Swaminathan S. (2015) Evidence suggesting a role of iron in a mouse model of nephrogenic systemic fibrosis. PLoS One 10(8):e0136563. PMID: 26305890
  • Shah SV, Shukla AM, Bose C, Basnakian AG, Rajapurkar M. (2015) Recent advances in understanding the pathogenesis of atherosclerosis in CKD patients. J Ren Nutr 25(2):205-208. PMID: 25556310
  • Swaminathan S, Bose C, Shah SV, Hall KA, Hiatt KM. (2013) Gadolinium contrast agent-induced CD163+ 1 ferroportin+ osteogenic cells in nephrogenic systemic fibrosis. Am J Pathol 183(3):796-807. PMID: 23867799
  • Bose C, Udupa KB. (2008) Erythropoietin enhancement of rat pancreatic tumor cell proliferation requires the activation of ERK and JNK signals. Am J Physiol Cell Physiol 294 (2):394-405. PMID: 18550701
  • Chowdhury P, Bose C, Udupa KB. (2007) Nicotine induced proliferation of isolated rat pancreatic acinar cells: effect on cell signaling and function. Cell Prolif 40:125-141. PMID: 17227300
  • Bose C, Zhang H, Udupa KB, Chowdhury P. (2005) Activation of p-ERK1/2 by nicotine in pancreatic tumor cell line AR42J: effect on proliferation and secretion. Am J Physiol Gastrointest Liver Physiol 289:G926-G934. PMID: 16051920
  • Udupa KB, Bose C. (2005) Identification of erythroid cell stimulating factor as a unique protein. Quiescin6: role in erythropoiesis. Blood 106(11):4270.
  • Bose C, Chidambaram B, Udupa KB. (2005) Age related alteration in hepatic acyl-CoA: cholesterol acyltransferase and its relation to LDL receptor and MAPK. Mech Aging Dev 126:740-751. PMID: 15888329
  • Bose C, Bhuvaneswaran C, Udupa KB (2004). Altered mitogen activated protein kinase signal transduction in human skin fibroblasts during in vitro aging: Differential expression of low density protein receptor. J Gerontol A Biol Sci Med Sci 59(2):126-135. PMID: 14999025
  • Bose C, Guo J, Zimniak L, Srivastava SK, Singh SP, Zimniak P, Singh SV. (2002) Critical role of allyl groups and disulfide chain in induction of Pi class glutathione transferase in mouse tissues in vivo by diallyl disulfide, a naturally occurring chemo preventive agent in garlic. Carcinogenesis 23(10):1661-1665.
  • Srivastava SK, Chauhan PMS, Agarwal SK, Bhaduri AP, Singh SN, Fatma N, Chatterjee RK, Bose C, Srivastava VML. (1996) Syntheses and antifilarial profile of 5-amino and 5,8-diaminoisoquinoline derivatives: A new class of antifilarial agents. Bioorg Med Chem Lett 22:2623-2628.
  • Bose C, Chatterjee RK, Bhaduri AP, Srivastava VML. (1996). Effect of two macrofilaricides on glucose metabolism in Litomosoides carinii and Acanthocheilonema viteae. Med Sci Res 24:387-389.
  • Bose C, Agarwal RA. (1996) Carbaryl induced changes in biogenic amine levels and acetylcholinesterase activity in the cockroach Periplaneta Americana. Biogen Amines 12:19-26.
  • Bose C, Agarwal SK, Chatterjee RK, and Srivastava VML. (1994). Carboline antifilarials: Effects on carbohydrate metabolizing enzymes in Litomosoides carinii female, Indian J Exp Biol 32:431-433.
  • Bose C. (1991) Malathion induced changes in biogenic amine levels and acetylcholine esterase activity in the cockroach, Periplaneta Americana. Curr Sci 60(12):707-709.
  • Bose C. (1991) Changes induced by Malathion in the carbohydrate metabolism of cockroach, Periplaneta Americana. Proc Nat Acad Sci India 61(B).
  • Bose C. (1991) Malathion and carbaryl induced changes in enzymes of cockroach Periplaneta Americana. Proc Nat Acad Sci India 61(B) II.
  • Bose C. (1990) In vivo inhibition of acetylcholine esterase by carbamate and organophosphorus compounds in the cockroach, Periplaneta Americana. Biol Memoirs 16:16-22.
  • Bose C. (1989) Contact toxicity of two insecticides to common cockroach, Periplaneta Americana. Biol Memoirs 14:175-180.
  • Manuscript  "Interleukin-1β drives NEDD8 nuclear-to-cytoplasmic translocation, fostering parkin activation via NEDD8 binding to the P-ubiquitin activating site" Meenakshisundaram Balasubramaniam, Paul Andrew Parcon, Chhanda Bose, Ling Liu, Richard A. Jones; Martin R. Farlow, Robert E. Mark, Steven W. Barger, Sue Griffin Journal of Neuroinflammation -JNEU-D-19-00605-Under Review.